Supriya Ghosh (Editor)

Mitogen activated protein kinase 9

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Covid-19
Species  Human
Entrez  5601
Human  Mouse
Ensembl  ENSG00000050748
Mitogen-activated protein kinase 9
Aliases  MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK, mitogen-activated protein kinase 9
External IDs  OMIM: 602896 MGI: 1346862 HomoloGene: 55685 GeneCards: MAPK9

Mitogen-activated protein kinase 9 is an enzyme that in humans is encoded by the MAPK9 gene.

Contents

Function

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation-induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Interactions

Mitogen-activated protein kinase 9 has been shown to interact with:

  • Grb2,
  • MAPK8IP1,
  • MAPK8IP2,
  • MAPK8IP3
  • P53, and
  • TOB1.
  • References

    Mitogen-activated protein kinase 9 Wikipedia


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