Mississippi Highway 149

Wiggins

MS 149 begins at an intersection with US 49 south of Wiggins in Stone County, heading north along two-lane undivided South Magnolia Drive. The road passes through a mix of woodland and industrial and business areas. Farther north, the highway comes to an interchange with MS 26, at which point MS 149 becomes concurrent with MS 29. The two highways continue north and pass businesses as a three-lane road with a center left-turn lane a short distance to the west of a Kansas City Southern Railway line. The name of the road changes to North Magnolia Drive at the College Avenue intersection. MS 29 splits from MS 149 by heading east while MS 149 curves northwest along with the railroad tracks and passes through wooded residential and commercial areas as a two-lane road. The tracks head further from the road as it continues through woods and development before MS 149 passes to the west of industry and comes to its northern end at another intersection with US 49 north of Wiggins.

Mount Olive

MS 149 begins at an intersection with US 49 south of Mount Olive in Covington County, heading north-northwest on two-lane undivided South Main Street. The road runs through woodland with some homes and enters Mount Olive, where it comes to an intersection with MS 35. The highway runs northwest through wooded neighborhoods before it passes businesses and parallels a Canadian National Railway line along Main Street. MS 149 turns west-northwest away from the tracks and gains median parking spaces as it runs through the downtown area of Mount Olive. Past downtown, the road becomes a two-lane divided highway as it heads past homes. MS 149 leaves Mount Olive and heads northwest on two-lane undivided Old Highway 49 North through wooded areas with some fields and homes, ending at another intersection with US 49.

Magee

MS 149 begins at a junction with US 49 south of Magee in Simpson County, heading north-northwest as a two-lane undivided Simpson Highway 149. The road passes through wooded areas with some homes before it enters Magee. The highway intersects MS 28 in an areas of businesses, with that route turning north for a concurrency with MS 149. The two highways head north and pass under a Canadian National Railway line before MS 28 splits to the east. MS 149 turns northwest and runs through commercial areas parallel to the railroad tracks, passing to the south of Magee General Hospital. The road forms a one-block concurrency with MS 541 south of the downtown area. MS 149 runs past more businesses before it curves to the west-northwest and runs through residential areas. The highway leaves Magee and continues west through rural areas of homes before it reaches an interchange with US 49 and crosses MS 545 a short distance later. MS 149 heads northwest through wooded areas with some homes, passing to the northeast of the Boswell Regional Center mental hospital in the community of Sanatorium. The highway continues northwest through forests and reaches its northern terminus at an intersection with US 49.

Mendenhall-Braxton

MS 149 begins at a junction with US 49 southeast of Mendenhall in Simpson County, heading northwest on two-lane undivided Simpson Highway 149. The road passes through wooded areas and intersects the western terminus of the eastern segment of MS 540. The highway continues west through forests before it enters Mendenhall and passes through residential and commercial areas a short distance to the north of a Canadian National Railway line. MS 149 passes to the south of the downtown area and continues past more development, curving northwest. The road comes to an interchange with MS 13 before it leaves Mendenhall and runs through forests. The highway crosses the Strong River before it enters D'Lo. Here, MS 149 turns north and passes homes and businesses, intersecting the eastern terminus of the western segment of MS 540. The road passes through residential areas and curves northwest, leaving D'Lo and heading through wooded areas with occasional homes. The highway continues through rural areas before it passes to the northeast of the wooded residential village of Braxton. MS 149 continues northwest through forested areas before it ends at another intersection with US 49.

Yazoo City-Silver City

MS 149 begins at an intersection with US 49 and MS 16 in Yazoo City, Yazoo County, heading west concurrent with MS 16 on East Broadway Street, a three-lane road with a center left-turn lane. The road heads through wooded areas with some homes and businesses, narrowing to two lanes and continuing west-northwest. The highway becomes lined with homes before it reaches the commercial downtown of Yazoo City, where the name changes to West Broadway Street at the Main Street intersection. MS 16/MS 149 heads out of the downtown area and crosses a Canadian National Railway line at-grade adjacent to the Yazoo City Station serving Amtrak's City of New Orleans train. The road runs past homes and businesses before it reaches an interchange with MS 3 at the western edge of Yazoo City. Past this interchange, the highway becomes unnumbered and crosses the Yazoo River before heading through a mix of farmland and woodland. MS 16/MS 149 crosses Broad Lake and continues through rural land, turning northwest and entering Humphreys County.

MS 16 splits from MS 149 by turning west, while MS 149 curves north and heads through agricultural areas. The road passes to the east of the residential town of Louise before it comes to an intersection with the eastern terminus of the western segment of MS 14. The highway continues north through farmland before it bends east to bypass the residential community of Midnight, with Old U.S. Highway 49W passing through Midnight. From here, MS 149 continues northeast through more rural areas before it comes to its northern terminus at an intersection with US 49W in Silver City.

Wiggins

The entire route is in Wiggins, Stone County.

Mount Olive

The entire route is in Mount Olive, Covington County.

Magee

The entire route is in Simpson County.

Mendenhall

The entire route is in Simpson County.