Mississippi Highway 145

Waynesboro

US 45 was fully rerouted out of Waynesboro in 2004, and the old alignment became MS 145.

The entire route is in Wayne County.

Shubuta

By 2001, US 45 bypassed Shubuta, and MS 145 was created for US 45's old routing.

De Soto–Meridian

Beginning in 1994, US 45 was upgraded to a divided highway outside Meridian. The old alignment continued to be in the state highway system. All of US 45's former routing in Lauderdale County became part of MS 145 in 1998. Two years later, US 45 was realigned onto a new divided highway in Clarke County, and old sections of US 45 became signed as MS 145.

Macon

By 1998, MS 145 was created after US 45 bypassed the town of Macon.

The entire route is in Noxubee County.

Aberdeen

MS 145 was created in 2000 after US 45 was rerouted to a new divided highway outside Aberdeen.

The entire route is in Aberdeen, Monroe County.

Nettleton

After US 45 was upgraded to a divided highway outside of Nettleton, MS 145 was designated along the former routing.

The entire route is in Nettleton.

Shannon–Booneville

US 45 was rerouted onto a freeway in Tupelo in 1977, no longer going through downtown Tupelo. The freeway was extended north and south in 1982 and 1984, and more of US 45 was moved. By 1986, the freeway extended as far as Shannon. About ten years later, US 45 was moved to a divided highway for Lee and most of Prentiss County, and the old alignment became MS 145.

Corinth

MS 145 was designated as the old routing of US 45 through Corinth in 1998.

The entire route is in Alcorn County.