Abolhassan was born in 1776 at Shiraz; he was the second son of Mirza Mohammad-Ali, a secretary of Nader Shah, and a daughter of Ebrahim Khan Kalantar, thus making him part of the influential Qavam family.
As a young man, Mirza Abolhassan was appointed as the governor of Shushtar. In April 1801, however, the family lost much of its power and influence during the downfall of Ebrahim, and thus all members of the family were persecuted by the Iranian government. While many were blinded or killed, some managed to flee. Mirza Abolhassan, however, was captured by Iranian troops, and was exiled in his native Shiraz. Abolhassan shortly afterwards fled from Shiraz, reaching Basra, where he then took a vessel to Hyderabad in India. Luckily, he was some time later pardoned, and went back to Iran, where he served Fath-Ali Shah Qajar, and quickly rose to high offices.
Abolhassan was chosen in 1809 as ambassador to lead a diplomatic mission to London at the court of the British king George III to seek support against growing ambitions of Russia in Caucasia. His escorting officer or "mehmandar" in Great Britain was Sir Gore Ouseley, who later encouraged Abolhassan to join the Free Masons in 1810. During his trip, Abolhassan kept a diary that was later published under the title, Heyratnameth (the book of wonders). This book, in which Abolhassan formulated his perception of Europe's modern achievements, was read widely in the Qajar court and later inspired sociopolitical movements, such as Iran's constitutional revolution.
Upon his return of that mission, Mirza Abolhassan obtained the title "Khan" and "Ilchi" (envoy). Abolhassan was later appointed as the main delegate for Iran in the Gulistan of 1813 and Turkmenchay treaties, under which Iran lost most of her Caucasian territories to Russia.
In 1818 Mirza Abolhassan Khan was sent again to London to find British support against Russia. That mission, however, failed, as Russia had meanwhile become an ally of the British against Napoleon I, and after the defeat of Napoleon I, France was no more a serious threat to British interests in Iran. Accordingly, good relations of Great Britain with Iran had a lesser weight to those with Russia.
In 1835, Abolhassan sealed himself in the Shah-Abdol-Azim shrine as a protest to Prime Minister Ghaem Magham Farahani. Abolhassan Khan later died in 1845.
Grandson Mirza Abolhassan Khan Shirazi, Mirza Ibrahim Khan, and his wife, who was born Amir Syed Asil-Al-Din Abdullah Al-Hosseini. And popular people were the special and general interest. And further caused by policies pursued his religious authority he had been using his father's name added power. After his commute to the court of political-religious power that he had in Persian by Naser al-Din Shah to improve his image than he used to. But after a while Shah at the instigation of the proximity of the power of this conspiracy and treason to his family after he feared their children in exile.
Mirza Ibrahim Khan has three children named Mirza Mohammad Ali Khan, Mirza Mahmud Khan and Mirza Masood Khan said that Mirza Ibrahim Khan and Mirza Mohammad Ali Khan and two children of his first and second Mirza Mahmoud Khan and his son and Mirza Abolqasim Khan to Darab Mirza Masood Khan and his sons Mirza Abolhassan Khan and Mirza Abolhossein Khan to Tehran and Rey exile. Now the family in the name of Mirzakhanyan, Mirzakhani in Tehran, Rey, Mirzaei in Darab, Moshiri known in Shiraz and Tehran. Moshiri family who are Mirza Masood Khan generation of high political power.