Symbol mir-592 miRBase family MIPF0000340 Domain(s) Eukaryota; | Rfam RF00877 RNA type microRNA | |
In molecular biology mir-592 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
Expression in cancers
Significantly altered expression of miR-592 has been observed between tumours deficient and proficient for mismatch repair in colon cancer. Expression levels are lower in the proficient form compared to the deficient, with a more than two-fold change. This altered expression has been proposed to reflect a reversion to regulatory programs seen in earlier undifferentiated and proliferative developmental states.
miR-592 expression is also altered in hepatocellular carcinoma; it has been shown to be downregulated along with nine other microRNAs.
References
Mir-592 microRNA precursor family Wikipedia(Text) CC BY-SA