Symbol mir-590 miRBase family MIPF0000418 Domain(s) Eukaryota; | Rfam RF00928 RNA type microRNA | |
In molecular biology mir-590 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
Nicotine-induced atrial remodelling
Downregulation of miR-590 by nicotine has been found to play a key part in the generation of atrial fibrosis by atrial structural remodelling. This downregulation sees the removal of post-transcriptional repression of TGF-β1 and TGF-β receptor type II (TGF-βRII), and consequent collagen production. miR-590 downregulation has further been shown to be mediated by activation of alpha-7 nicotinic acetylcholine receptors (α7-nAChRs).
References
Mir-590 microRNA precursor family Wikipedia(Text) CC BY-SA