Samiksha Jaiswal (Editor)

Microtubule associated protein 2

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Covid-19
Species  Human
Entrez  4133
Human  Mouse
Ensembl  ENSG00000078018
Microtubule-associated protein 2
Aliases  MAP2, MAP2A, MAP2B, MAP2C, microtubule associated protein 2
External IDs  MGI: 97175 HomoloGene: 1779 GeneCards: MAP2

Microtubule-associated protein 2 is a protein that in humans is encoded by the MAP2 gene.

Contents

Function

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neuritogenesis. MAP2 serves to stabilize microtubules (MT) growth by crosslinking MT with intermediate filaments and other MTs. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dendrites, implicating a role in determining and stabilizing dendritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described.

Interactions

MAP2 has been shown to interact with Grb2, NEFL and MYO7A. MAP2 is suspected of interacting with tubulin.

References

Microtubule-associated protein 2 Wikipedia


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