Chamuel grew up in Wellesley, Massachusetts. Born to Jewish Egyptian-American parents Joalie Davie and Jacques Chamuel, her father played the violin and was an acoustical engineer. She started on piano and violin at an early age. In seventh grade she started to sequence music on a synthesizer, sing and compose. She graduated from Wellesley High School and studied performing arts technology at the University of Michigan.
In 2007 Chamuel joined the Ann Arbor, Michigan-based band Ella Riot. Initially the band was instrumental, and her addition as lead vocalist became a turning point in the band's direction. The band's name was in part a tribute to Ella Fitzgerald who was an inspiration to Chamuel. The band toured extensively and released two definitive works, Dancethink and Love Child. The band went into hiatus in October 2011.
In a 2010 interview with AfterEllen, Chamuel spoke about being out and lesbian in the music industry, staying true to herself, and artists that inspired her such as Elton John and Ani DiFranco.
After Ella Riot, she moved to Amherst, Massachusetts, and worked independently. She released an album titled s/he, an EP titled All the Pretty People and an EP titled EP 1 in partnership with other artists. She released remix music with original lyrics and vocal compositions and collaborated with several musicians as a featured artist. Chamuel names Max Martin and Imogen Heap as major influences. She was influenced by the vocal styles of Heap and Ella Fitzgerald and said they "opened me up to the idea that one could sing melodies like an instrument."
Chamuel took part in the fourth season of NBC's The Voice. In the blind audition she sang Katy Perry's "I Kissed a Girl" and chose Usher as her coach. In her first live performance she sang Cyndi Lauper's "True Colors". Over the next four live performances she was voted into the Top 5. Her rendition of "Just Give Me a Reason" was called a killer performance by Pink's official website. Her rendition of Taylor Swift's "I Knew You Were Trouble" received an enthusiastic approval from Swift and charted on the Billboard Hot 100. In the final round she sang Annie Lennox's "Why" and U2's "One" in a duet with Usher. She came in second place.
Chamuel released All I Want in September 2013. The album debuted at number 6 on the U.S. Dance/Electronic Albums chart. She called the album her "solo electronic project" and said her studio work as The Reverb Junkie focuses on creative sound works, whereas the work released under her own name has more of a pop focus. In late 2013 she spoke at a fundraiser for "Voices from Inside", an organization dedicated to empowering women. She released a single titled "Go Down Singing" and spoke at a TEDx gathering about the role of music in shaping one's sense of home.
In January 2014 Chamuel and producer Arjun Singh released an EP titled The Drift. The EP features hip hop artist Isaac Castor. She released a song on Valentine's Day titled "Made for Me" and an EP titled EP 2 in April 2014. This was her second EP in partnership with producer David Gonzalez. In 2014 she performed several shows in the U.S. and Ireland, including a seventeen city U.S. tour.
She released Face the Fire in February 2015. She said as a teenager she was obsessed with pop hits on Top 40 radio and in this album she wanted to produce well-crafted pop music. The album debuted at number 21 on the U.S. Independent Albums chart. She performed an acoustic version of "Golden" on VH1's Morning Buzz show.
Chamuel released an EP titled I Am in November 2015 under The Reverb Junkie moniker. She co-wrote and produced "Hang out with You", a song by her girlfriend Mary Lambert. She released an EP titled Feel It in August 2016. This was the first of several works being produced, each in a different style. In interviews leading to the EP's release, Chamuel spoke about her focus on all aspects of music production. She released a self-produced album titled Insights & Turnpikes in May 2017. The album includes several stripped-down acoustic songs.
Released as: Michelle Chamuel–1, The Reverb Junkie–2, s/he–3.