Methylamine—glutamate N methyltransferase

In enzymology, a methylamine-glutamate N-methyltransferase (EC 2.1.1.21) is an enzyme that catalyzes the chemical reaction

Thus, the two substrates of this enzyme are methylamine and L-glutamate, whereas its two products are NH₃ and N-methyl-L-glutamate.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is methylamine:L-glutamate N-methyltransferase. Other names in common use include N-methylglutamate synthase, and methylamine-glutamate methyltransferase. This enzyme participates in methane metabolism.