Routes of
administration Oral Biological half-life 7-8 hours PubChem CID 65700 | ATC code none CAS Number 21730-16-5 Molar mass 238.33 g/mol | |
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Legal status In general: ℞ (Prescription only) | ||
Metapramine (trade names Prodastene, Timaxel) is a tricyclic antidepressant (TCA) developed by Rhone Poulenc that was introduced for the treatment of depression in France in 1984. In addition to its efficacy against affective disorders, it also has analgesic properties, and may be useful in the treatment of pain.
Metapramine has desipramine-like effects, acting as a norepinephrine reuptake inhibitor without affecting the reuptake of serotonin or dopamine. It has also been shown to act as a low-affinity NMDA receptor antagonist. Metapramine's direct effects on serotonin, histamine, and muscarinic acetylcholine receptors have not been assayed, but uniquely among most TCAs, it has anecdotally been reported to lack anticholinergic effects.
References
Metapramine Wikipedia(Text) CC BY-SA