Symbol MBTPS2 Entrez 51360 OMIM 300294 | Alt. symbols S2P HUGO 15455 RefSeq NM_015884 | |
Membrane-bound transcription factor site-2 protease, or site-2 protease (S2P) for short, is an enzyme (EC 3.4.24.85) encoded by the MBTPS2 gene which liberates the N-terminal fragment of sterol regulatory element-binding protein (SREBP) transcription factors from membranes. S2P cleaves the transmembrane domain of SREPB, making it a member of the class of intramembrane proteases.
S2P endopeptidase (EC 3.4.24.85) is an enzyme. This enzyme catalyses the following chemical reaction
Cleaves several transcription factors that are type-2 transmembrane proteins within membrane-spanning domains. Known substrates include sterol regulatory element-binding protein (SREBP)-1, SREBP-2 and forms of the transcriptional activator ATF6.This enzyme belongs to the peptidase family M50.
References
Membrane-bound transcription factor site-2 protease Wikipedia(Text) CC BY-SA