Neha Patil (Editor)

Melanin concentrating hormone receptor

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Symbol
  
MCHR1

Entrez
  
2847

OMIM
  
601751

Alt. symbols
  
GPR24

HUGO
  
4479

RefSeq
  
NM_005297

Two Melanin-concentrating hormone receptors (MCHR) have recently been characterized: MCH-R1 and MCH-R2. These two receptors share approximately 38% homology.

  • MCH-R1 is expressed in all mammals.
  • MCH-R2 is only found in some primates and carnivores including dogs, ferrets and man.

    • Clinical significance

    Antagonists might be useful in the treatment of obesity and anxiety and depression. An agonist might have possible utility as a treatment for osteoporosis and insomnia

    Research is ongoing for antagonists affecting MCH receptors R1 and R2.

    References

    Melanin-concentrating hormone receptor Wikipedia
    (Text) CC BY-SA