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The Mehmet Bey Mosque (Greek: Τέμενος Μεχμέτ Μπέη), locally also known as Hagia Sophia (Αγιά Σοφιά), is a 15th-century Ottoman mosque in the city of Serres in northern Greece.
The mosque was built by the eponymous Mehmet Bey in 1492–93. Mehmet was a son-in-law of Sultan Bayezid II, having married the princess Selcuk Hatun. The couple lived in the city in the late 15th century and endowed it with several other buildings, none of which survive. It had already fallen out of use by the late 19th century, when it was severely damaged by floods of the nearby stream of Agioi Anargyroi.
The mosque is built of carefully carved yellow limestone ashlar masonry, except for the domed parts, which are built of brick. It consists of a spacious square central prayer hall, topped by a single dome with a diameter of 14.58 m. Four smaller rooms covered by half-domes are arranged two each on the east and west sides of the central space, while the southern face features a pentagonal portico containing the mihrab. The main entrance is located on the northern wall, topped by the founder's dedicatory inscription and fronted by a portico comprising five arches supported by columns of white marble with exquisitely carved capitals. The central arch is topped by a semi-spherical dome, while the arches on either side are topped by funnel domes. Originally, all the domes of the mosque were roofed in lead, and the interior walls plastered, while travellers report that a beautiful garden surrounded the building.
Despite being the oldest and largest of the city's surviving mosques, today the building is derelict and unused.