McClain (Gaelic: Mac Gill-Eain) is a surname. Notable people with the surname include:
Albritton McClain (contemporary), American rock guitaristCady McClain (b. 1969), American actressCharly McClain (b. 1956), American country music singerChina Anne McClain (b. 1998), American actress and singer, one of the 3McClainGirls and McClain SistersDave McClain (coach) (b. 1938), American football coachDave McClain (drummer) (contemporary), American heavy metal drummerDavid McClain (president) (contemporary), American academic, President of the University of HawaiiDewey McClain, American football player, politician from GeorgiaDwayne McClain (b. 1973), American professional basketball playerEdward McClain (b. 1944), American politician from AlabamaFrank B. McClain (1864–1925), American politician from PennsylvaniaJimmy McClain (b. 1980), American football playerJohnathan McClain (contemporary), American stage and television actorLauryn McClain (b. 1997), American actress and singer, one of the 3McClainGirls and McClain SistersLeonard MacClain (1899-1967), American organistLe'Ron McClain (b. 1984), American professional football playerLeanita McClain (1951–1984), American journalist and commentatorMichael Sean McClain (b. 1975), American fencerPatricia McClain (b. 1954), American model and Playboy centerfoldScott McClain (b. 1972), American professional baseball playerSierra McClain (b. 1994), American actress and singer, one of the 3McClainGirls and McClain SistersSteve McClain (b. 1962), American basketball coachTed McClain (b. 1946), American professional basketball playerThaddeus McClain (1876–1935), American track and field Olympic athleteFictional people:
Paul McClain, character in the Australian soap opera NeighboursShauni McClain, character in the American TV series Baywatch