His work has impact in various fields of mass spectrometry-based proteomics:
The peptide sequence tag approach developed at the EMBL was one of the first methods for the identification of peptides based on mass spectra and genome data.
Nano-electrospray (an electrospray technique with very low flow rates) was the first method that allowed femtomole sequencing of proteins from polyacrylamide gels.
A recently developed metabolic labeling technique called SILAC (stable isotope labeling with amino acids in cell culture) is widely used in quantitative proteomics.
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Awards and honors
1991: Malcom Award by the journal Organic Mass Spectrometry
1996: Mattauch Herzog Prize in Mass Spectrometry
1997: Hewlett-Packard Prize for Strategic Research in Automation of Sample Preparation
1998: Edman Prize by the "Methods in Protein Structure Analysis" Society