Name Matthias Hentze | Nationality German Citizenship German Fields Molecular biology | |
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Born January 25, 1960 (age 64) Wiedenbruck, Germany ( 1960-01-25 ) Alma mater Westfalische Wilhelms-Universitat Munster Thesis "Influence of amino acid analogs on maturation, transport and stability of cathepsin D in human skin fibroblasts" (1984) Similar Edith Heard , Leo Szilard , James Watson | ||
Prof matthias hentze rna binding proteins smart phones and the sun
Matthias Werner Hentze, MD (born 25 January 1960 in Wiedenbrück, West Germany) is a German scientist. He is the Director of the European Molecular Biology Laboratory (EMBL) and Professor of Molecular Medicine at Heidelberg University.
Contents
- Prof matthias hentze rna binding proteins smart phones and the sun
- Biography
- Research
- Honors and awards
- Editorial Boards
- References
Biography
Matthias Hentze studied medicine in the UK at the medical schools at the University of Southampton, University of Oxford, University of Glasgow and University of Cambridge, and in Germany at the Westfälische Wilhelms-Universität, Münster from which he qualified in 1984. In the same year, he received his M.D. degree; he wrote a dissertation on the role of glycosylation in lysosomal enzyme stability with Kurt von Figura as his advisor.
After a short phase of clinical work Hentze became a postdoctoral fellow in Dr. Richard Klausner’s laboratory at the National Institutes of Health in 1985. In 1989, he joined the European Molecular Biology Laboratory in Heidelberg as an independent group leader. At the age of 30, he obtained the Habilitation from the Ruprecht-Karls University in Heidelberg. He served as Dean of the EMBL International Ph.D. Programme from 1996 until 2005, when he became Associate Director of the EMBL and Professor for Molecular Medicine at the University of Heidelberg. Together with Prof. Andreas Kulozik of the Medical Faculty of Heidelberg University, Hentze co-founded the Molecular Medicine Partnership Unit (MMPU) in the early 2000s and serves as its Co-Director. Technology he invented was licensed to Anadys Pharmaceuticals when that company pivoted and was renamed from Scriptgen Pharmaceuticals around 2000.
In 2013, Hentze became the Director of EMBL, advising and supporting EMBL's Director General, Iain Mattaj.
Research
In 1987, Hentze and his colleagues discovered iron-responsive elements that regulate the translation of mammalian mRNA into proteins. He has also studied the relationship between iron metabolism and disease and diseases of RNA metabolism, especially those relating to the Nonsense-mediated decay pathway and RNA 3′-end formation. Since around 2010 Hentze has studied RNA-binding enzymes that connect cellular metabolism and gene expression.
Hentze has hypothesized ways that genes are regulated by interactions among RNA, enzymes and metabolites, and calls this set of interactions "REM networks". Work following the hypothesis has identified many formerly unknown RNA-binding proteins in the stem cells of mammals and yeast.