Puneet Varma (Editor)

Matriptase

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EC number
  
3.4.21.109

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

CAS number
  
241475-96-7

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

Matriptases (EC 3.4.21.109) are an enzyme family. This enzyme catalyses the following chemical reaction

Cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position

This trypsin-like integral-membrane serine peptidase has been implicated in breast cancer invasion and metastasis.

Human matriptases

  • ST14, also known as matriptase
  • TMPRSS6, also known as matriptase 2
  • References

    Matriptase Wikipedia