Matriptase

Updated on Dec 27, 2024

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EC number 3.4.21.109 IntEnz IntEnz view ExPASy NiceZyme view		CAS number 241475-96-7 BRENDA BRENDA entry KEGG KEGG entry

Matriptases (EC 3.4.21.109) are an enzyme family. This enzyme catalyses the following chemical reaction

Cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position

This trypsin-like integral-membrane serine peptidase has been implicated in breast cancer invasion and metastasis.

Human matriptases

ST14, also known as matriptase

TMPRSS6, also known as matriptase 2

References

Matriptase Wikipedia

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