Rosenthal sold the first screenplay he wrote, which came out theatrically as The Legend of Billie Jean. This was followed by such films as The Jewel of the Nile, Superman IV: The Quest for Peace, Star Trek VI: The Undiscovered Country, The Beverly Hillbillies, Tim Burton's Planet of the Apes, Mona Lisa Smile, Flicka, Mercury Rising, Mighty Joe Young and The Sorcerer's Apprentice. He also did uncredited work on I, Robot and Eragon.
Rosenthal co-wrote (with Konner) and directed The In Crowd for Orion Studios.
Rosenthal is a voting member of the Academy of Motion Pictures Arts & Sciences. He was featured in Tales From The Script: 50 Hollywood Screenwriters Share Their Stories and in Why We Write: 25 Top Screenwriters Share Their Stories (Sillman-James Press).
Rosenthal, working with Konner, did non-credited work on I, Robot as well. In the original draft, the Bridget Moynahan character was the "hidden robot-human hybrid". Realizing that this dilemma would explain Will Smith's antipathy towards robots, Rosenthal created a central character who had been maimed by robots. Rosenthal and Konner also wrote the sequence where Smith uncovers the escaped robot in the factory by shooting into the lines of robots.
Rosenthal recorded a DVD commentary for Superman IV: The Quest for Peace for the Deluxe Edition of the film in 2006. Here he discusses the film's original intentions and deleted scenes. Rosenthal has also described the final film as producer Cannon Films stabbing star Christopher Reeve in the back.
According to Rosenthal, Reeve and director Sidney J. Furie begged Cannon Films to film a sequence in New York in front of the real United Nations Building because filmgoers were very familiar with that location, but the Milton Keynes setting looked more like a municipal auditorium,. However, Cannon refused because they were "pinching pennies at every step".
Rosenthal also revealed that he and writer Lawrence Konner wanted Reeve to play Nuclear Man as well as his dual roles of Superman and Clark Kent in the film. They imagined the villain being a darker version of the hero in the cloning process. This would have been financially expensive and was already explored in minor detail in Superman III. Therefore, Cannon decided instead to hire Mark Pillow for the part of Nuclear Man.
Also according to Rosenthal, there are approximately 45 minutes of the film that have not been seen by the public after they were deleted following a failed Southern California test screening.