Nationality United States Name Marius Sudol | ||
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Institutions National University of Singapore (Republic of Singapore)Geisinger Clinic (PA)Mount Sinai School of Medicine (NY) Academic advisors Andrzej Klein, Edward Reich, Wolf-Dieter Schleuning, Hidesaburo Hanafusa, Paul Klotman Known for Modular Protein Domains Fields Molecular and Cellular Biology Institution National University of Singapore, Icahn School of Medicine at Mount Sinai | ||
Alma mater Rockefeller University | ||
Marius Sudol, PhD, is an American molecular and cellular biologist. He was born in 1954 in Tarnow, Poland. In 1978, he immigrated to the United States to study at The Rockefeller University in New York City. Among his most significant achievements to date are the identification of a modular protein domain, known as the WW domain, and the characterization of its cognate ligands. In 2004, together with a research team at AxCell-Cytogen company, Marius Sudol reported the first comprehensive protein interaction map for a human modular domain. Today, the WW domain is known to mediate critical signals in tumor suppressor networks, including the Hippo signaling pathway. More importantly, syndromes such as the Golabi-Ito-Hall syndrome of intellectual disability and Liddle syndrome of hypertension are caused by loss-of-function point mutations in the WW domain or its cognate ligands.
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The research conducted in Marius Sudol’s laboratory and those of his collaborators over the past two decades has directly contributed to a systems biology level understanding of signaling networks from the perspective of modular protein domains. As a co-founder and co-leader of the Protein Modules Consortium, he advocates systems biology approaches and synthetic biology strategies in designing therapeutic interventions based on the knowledge of the structure and function of protein modules.
Over the course of his scientific career spanning more than three decades, Marius Sudol has authored 150 publications, including original research articles and invited reviews in refereed journals as well as numerous book chapters. These publications have been collectively cited over 13,000 times. His current work focuses on the role of WW domain-containing proteins in the Hippo tumor suppressor network and Golabi-Ito-Hall syndrome of intellectual disability.
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Marius Sudol was educated at the Staszic grammar school and III Lyceum High School in Tarnow, Poland. He completed his undergraduate studies in his native country at the Jagiellonian University in Kraków, majoring in molecular biology. In 1983, he earned a PhD degree at The Rockefeller University in NYC, USA, in molecular and cellular biology, and continued on at his alma mater as a postdoctoral fellow and faculty member until he became an Associate Professor at Mount Sinai School of Medicine in 1995. In 2004, Marius Sudol moved his laboratory to the Weis Center for Research at Geisinger Health Systems in Pennsylvania, while continuing his academic association with the Mount Sinai School of Medicine in NYC as an adjunct faculty member in the Medicine Department. In 2014, he joined the Department of Physiology at the National University of Singapore with joint appointments at the Mechanobiology Institute and the Institute of Molecular and Cell Biology, A*STAR (Agency for Science, Technology and Research), in the Republic of Singapore. Marius Sudol is actively involved in leading the Protein Modules Consortium and serves on Editorial Boards of several journals, including “Oncogene”, “Science Signaling” and "Journal of Biological Chemistry".