Specialty neurology ICD-9-CM 341.8 eMedicine neuro/204 | ICD-10 G37.1 DiseasesDB 31494 MeSH D054319 | |
Marchiafava–Bignami disease is a progressive neurological disease of alcoholism, characterized by corpus callosum demyelination and necrosis and subsequent atrophy.
Contents
Eponym
It was first described in 1903 by the Italian pathologists Amico Bignami and Ettore Marchiafava in an Italian Chianti drinker. In this patient, Marchiafava and Bignami noticed that the middle two-thirds of the corpus callosum were necrotic.
Causes
It is classically associated with chronic alcoholism and sometimes associated nutritional deficiencies.
References
Marchiafava–Bignami disease Wikipedia(Text) CC BY-SA