Marc Silvestri was born on March 29, 1959 in Palm Beach, Florida. Silvestri first discovered comics through his cousin, who was an avid collector. It was during visits to his cousin's house that Silvestri would become familiar with artists such as Jack Kirby, Bernie Wrightson and John Buscema. Silvestri names Wrightson, Buscema and Frank Frazetta as his biggest influences.
Silvestri began his career drawing issues for DC Comics and First Comics. He joined Marvel Comics in the late 1980s, and became the penciller on Uncanny X-Men from 1987 to 1990. He subsequently spent two years pencilling its spin-off title Wolverine.
In 1992, Silvestri became one of the original seven artists — along with Jim Lee, Whilce Portacio, Rob Liefeld, Erik Larsen, Todd McFarlane and Jim Valentino — to form the breakaway comics company Image Comics. Silvestri's stable of titles was published under the imprint Top Cow with the first title released being Cyberforce. Besides his art, Silvestri was also scripter (and co-plotter) on the Top Cow title Codename: Stryke Force. Many of Silvestri's stories were scripted by his brother, Eric Silvestri.
Disputes among the Image partners led to Silvestri briefly leaving the publisher in 1996, but he soon returned after Liefeld severed his own ties with Image.
Top Cow's successes include the titles Witchblade, The Darkness, Inferno Hellbound (publication of which was interrupted for unknown reasons) and Fathom.
In 2004 Silvestri made a brief return to Marvel to pencil several issues of X-Men, collaborating with writer Grant Morrison. Later in the year, he launched a new Top Cow title, Hunter-Killer with writer Mark Waid. He provided covers for the Marvel Comics mini-series, X-Men: Deadly Genesis by Ed Brubaker and Trevor Hairsine.
In June 2006 Top Cow released a Cyberforce #0 featuring the art talents of Silvestri.
In late 2007 (cover date December), he pencilled the X-Men: Messiah Complex one-shot, as well as many covers in the crossover of the same name that followed.
Silvestri executive produced the anime adaptation of Witchblade.
He continued his work on X-Men, penciling the first installment, in the form of a one-shot Uncanny X-Men/Dark Avengers crossover Utopia in 2009. That same year, he contributed to the crossover miniseries Image United, penciling all the characters he created during his run at Image that featured in the story.
In 2012, Silvestri was one of several artists to illustrate a variant cover for Robert Kirkman's The Walking Dead #100, which was released July 11 at the San Diego Comic-Con.
Silvestri is married to Bridget Silvestri.
His favorite TV shows include Breaking Bad, his favorite films are Forbidden Planet, Alien and Dr. Strangelove, and he says that he listens to down-tempo chill music while working, and alternative rock at other times.