EC number 4.1.2.10 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 9024-43-5 BRENDA BRENDA entry KEGG KEGG entry | |
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In enzymology, a mandelonitrile lyase (EC 4.1.2.10, (R)-HNL, (R)-oxynitrilase, (R)-hydroxynitrile lyase) is an enzyme that catalyzes the chemical reaction
mandelonitrileHence, this enzyme has one substrate, mandelonitrile, and two products, hydrogen cyanide and benzaldehyde.
This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is mandelonitrile benzaldehyde-lyase (hydrogen cyanide-forming). Other names in common use include hydroxynitrile lyase, (R)-oxynitrilase, oxynitrilase, D-oxynitrilase, D-alpha-hydroxynitrile lyase, and mandelonitrile benzaldehyde-lyase. This enzyme participates in cyanoamino acid metabolism. It has 2 cofactors: flavin, and flavoprotein.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1JU2.