Species Human Entrez 9961 | Human Mouse Ensembl ENSG00000013364 | |
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Aliases MVP, LRP, VAULT1, major vault protein External IDs MGI: 1925638 HomoloGene: 3752 GeneCards: MVP | ||
Major vault protein is a protein that in humans is encoded by the MVP gene. 78 copies of the protein assemble into the large compartments called vaults, illustrated and discussed in the article on Vault (organelle).
Contents
Function
This gene encodes the major vault protein which is a lung infection resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.
Interactions
Major vault protein has been shown to interact with Estrogen receptor alpha, PTEN and PARP4.