Macarena Achaga Figueroa was born in Mar del Plata, Argentina. Her parents are architects. She is the oldest child and has a brother named Santiago, who is eight years younger. At 15, Achaga began her career as a model, travelling up to five hours every week by bus from Mar del Plata to Buenos Aires for jobs. She signed with Pink Model Management in Buenos Aires. Eventually, she signed with Mulittalient Agency, also located in Buenos Aires. At 18, she moved to Buenos Aires to further pursue her modeling career.
Achaga began her career at 15 as a print model in her native Argentina with Pink Models Management based in Buenos Aires. She has modeled for various Argentine clothing brands like Sweet Victorians, Doll Fins, and Muaaa. She later signed as a model to Multitalent Agency in Buenos Aires, Argentina. As a commercial and fashion model, Achaga has appeared in dozens of print and campaign work. She appeared in a commercial for Marinela cookies in 2010. Her print work credits for magazines include, ParaTeens and Código Teen. Achaga appeared on the cover of Joy magazine and Para Ti in 2011. At 18, she worked briefly in Mexico and France for modelling jobs. In August 2009, she did editorial work for Cosmopolitan Argentina and appeared in the Spring/Summer 2012 print campaign for handbags for the brand CLOĒ in Mexico. In August 2011 and 2013, she appeared in an editorials for InStyle Mexico.
In October 2013, she appeared in a breast cancer awareness ad campaign in Mexico for Tommy Hilfiger handbags. She also appeared in a web mini-series ad for Nescafé Dolce Cafe, promoting the brand alongside Gossip Girl: Acapulco in Mexico. Achaga appeared on the cover and in an editorial spread modeling bridal dresses for Hola magazine's special "Novias" edition in November 2014.
In October 2015, Achaga and actor Gonzalo Garcia Vivanco appeared in an autumn print campaign for Banana Republic in Mexico.
Achaga's first television job was co-hosting the Argentine version of the MTV Latin America music show Los 10+ Pedidos with Gabo Ramos in 2010. She left the show in 2011, following her casting in the Nickelodeon Latin America and Canal 5 television series Miss XV.
Achaga continued working as a model in Mexico throughout 2011. In June 2011, she was in Mexico City attending workshop at Televisa San Ángel, where she was spotted by producer, Pedro Damián, in the cafeteria. Damián invited her to audition for Miss XV, the network's new tween-oriented musical television series. Achaga was one of eight actresses considered in the final castings for the role of the antagonist, "Leonora". In August 2011, Achaga was confirmed as the female antagonist, "Leonora Martínez", for Miss XV. Achaga is the only Argentine cast member in the ensemble. Filming for the television series required Achaga to make the permanent move to Mexico City where production on the show lasted from October 2011 to June 2012. The show premiered on Nickelodeon Latin America on April 16, 2012. On Canal 5, the show began airing episodes on May 14, 2012 for Latin America. In spite of its success in Mexico, the show was not renewed for a second season.
In January 2013, Achaga was officially confirmed as "Jenny Parra" in Gossip Girl: Acapulco, the Mexican remake of the hit United States television show, Gossip Girl. In order to be cast on the show, co-producer Andrés Tovar, required Achaga to get rid of her Argentine accent by taking speech lessons in order to more accurately portray a Mexican character. Mexican producer Pedro Torres co-produced the show along with a collaboration from Warner Channel International and Mexican production agency El Mall. Filming for the series began in late January in Acapulco, Mexico and ended in May 2013. The show premiered on August 5, 2013 for the channel Golden Premiere in Mexico. The series began airing on the Mexican television stations Telehit in September; it aired in the U.S. on UniMas. It began airing on Canal 5 on November 11, 2013. On January 14, 2014, producer Pedro Torres announced that Gossip Girl: Acapulco was cancelled. In July 2013, Achaga filmed El Librito Rojo, a short film in which she stars as the protagonist, in Guanajuato, Mexico. Filming was conducted in two days.
In January 2014, she filmed Páginas Negras, a horror themed television series starring Alfonso Herrera in Buenos Aires. A trailer for the show was released on Vimeo in July of that same year. A release date has not been set, but it is slated to air on the Argentine network, Space in Latin America. She filmed a role in the critically acclaimed Peruvian drama film, ''Magallanes, in 2014. The film later screened internationally, and is scheduled for a showing at the Miami International Film Festival on March 13, 2016. In late March 2014, Achaga traveled to Pucón, Chile to begin rehearsals for Sitiados, a new historical drama television series co-produced by the Chilean network TVN and FOX International Channels. Set from 1598 to 1601, the series is inspired by the true account of a group of Mapuche who held 500 Spanish prisoners in Villarrica, Chile during the Arauco War. Production began on April 8, 2014 in Pucón. Filming concluded in July 2014 after nearly 4 months. The series premiered exclusively on May 2, 2015 on the subscription service, FOXPlay+, in Latin America. One week later, it premiered on television on Fox Latin America on May 10, 2015.
From October 2014 to April 2015, she filmed the third season of the Fox Latin America television musical drama, Cumbia Ninja, in Bogotá, Colombia. The third and final season of Cumbia Ninja, consisting of 17 episodes, premiered in Latin America on October 29, 2015 for Fox Latin America. In early October 2015, Achaga travelled to Lima, Peru to begin filming the television drama, El regregso de Lucas. The show is a collaboration produced by both the Argentine network, Telefe and the Peruvian network, América Televisión. A total of 60 episodes are expected. The show premiered on November 9, 2016 in Peru.
In mid-2016, Achaga returned to Mexico City and began filming the television drama, "La piloto", slated to air sometime in 2017. The series will have 80 episodes.
In the summer of 2011, Macarena attended the final castings for Miss XV in Mexico City. Originally, the producers were not looking for a sixth member, but decided to hold a casting search in July 2011 to find a third female member. In August 2011, she was confirmed as the cast's final female member. As a member of the ensemble cast, Macarena also joined the pop group Eme 15 as the sixth and final band member. The remaining five members were Paulina Goto, Elezar Gómez, Natasha Dupeyrón, Yago Muñoz, and Jack Duarte. The band released their first music video, Wonderland, on April 4, 2012. The video was filmed in October 2011 at Las Pozas, a garden in Xilitla, San Luis Potosí. Wonderland was officially released for digital download on iTunes in Mexico on April 24, 2012.
The band separated following their final concert on January 5, 2014 in Acapulco, Mexico.
Following her casting in Miss XV in August 2011, Achaga moved to Mexico City where she currently resides. In March 2013, she became a vegetarian. Achaga's relationship with Mexican actor, Sebastian Zurita, was confirmed in February 2014. The couple separated at the end of 2014.