MacManus is a family name that may refer to:
Annie MacManus (a.k.a. Annie Mac) (b. 1988) - Irish DJ and television presenter
Arthur MacManus (1889–1927) - Scottish trade unionist, political activist
Diana MacManus (born 1986) - US athlete in swimming
Dony MacManus (fl. 1990–present) - Irish sculptor, educator
Emily MacManus (1886–1978) - Irish nurse, OBE recipient
Declan MacManus (a.k.a. Elvis Costello) (b. 1954) - English musician, singer and songwriter (son of Ross MacManus)
Francis MacManus (1909–1965) - Irish novelist
Henry MacManus (c. 1810–1878) - Irish painter
Joseph MacManus (1970–1992) - member in the Sligo Brigade of the Provisional Irish Republican Army
Rosina MacManus (d. 2008) - Irish supporter of Camogie Association
Ross MacManus (b. 1927) - British musician (father of Elvis Costello)
Seán MacManus (politician) (b. 1950) - Irish political figure, father of Joseph MacManus
Seumas MacManus (1869–1960) - Irish author, dramatist, poet
Steve MacManus (b. 1953) - British comic writer, author, editor
Terence MacManus (c. 1811–1861) - Irish rebel
Theodore F. MacManus (1872–1940) - US advertisingman
Thomas MacManus (b. 1977) - Irish lawyer
Tristan MacManus (b. 1982) - Irish dancer
