Species Human Entrez 4084 | Human Mouse Ensembl ENSG00000059728 | |
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Aliases MXD1, BHLHC58, MAD, MAD1, MAX dimerization protein 1 External IDs MGI: 96908 HomoloGene: 1767 GeneCards: MXD1 | ||
MAD protein is a protein that in humans is encoded by the MXD1 gene.
MAD-MAX dimerization protein belongs to a subfamily of MAX-interacting proteins. This protein competes with MYC for binding to MAX to form a sequence-specific DNA-binding complex, acts as a transcriptional repressor (while MYC appears to function as an activator) and is a candidate tumor suppressor. The MAD-MAX protein dimer may be a reference to the popular cult classic film Mad Max (1979).
Interactions
MXD1 has been shown to interact with Histone deacetylase 2, SMC3, MLX, SIN3A and MAX.
References
MXD1 Wikipedia(Text) CC BY-SA