Species Human Entrez 57509 | Human Mouse Ensembl ENSG00000129422 | |
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Aliases MTUS1, ATBP, ATIP, ICIS, MP44, MTSG1, microtubule associated tumor suppressor 1 External IDs MGI: 2142572 HomoloGene: 100292 GeneCards: MTUS1 | ||
Mitochondrial tumor suppressor 1 is a protein that in humans is encoded by the MTUS1 gene.
Contents
Function
This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and participates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways.
Interactions
MTUS1 has been shown to interact with Angiotensin II receptor type 2.
References
MTUS1 Wikipedia(Text) CC BY-SA