MS 245

MS-245 is a tryptamine derivative which is used in scientific research. It acts as a selective 5-HT₆ receptor antagonist with a K_i of 2.3 nM, and was derived through structure-activity relationship development of the selective 5-HT₆ agonist EMDT. It has been used as a lead compound for further development of tryptamine-derived 5-HT₆ antagonists. In animal studies it has been shown to boost the activity of, but not substitute for, both amphetamine and nicotine.