Species Human Entrez 64963 | Human Mouse Ensembl ENSG00000181991 | |
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Aliases MRPS11, HCC-2, MRP-S11, S11mt, mitochondrial ribosomal protein S11 External IDs MGI: 1915244 HomoloGene: 32554 GeneCards: MRPS11 | ||
28S ribosomal protein S11, mitochondrial is a protein that in humans is encoded by the MRPS11 gene.
Function
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that contains a high level of sequence similarity with ribosomal protein S11P family members.