Entrez 4330 | Ensembl ENSG00000169184 | |
Aliases MN1, MGCR, MGCR1, MGCR1-PEN, dJ353E16.2, meningioma (disrupted in balanced translocation) 1, MN1 proto-oncogene, transcriptional regulator External IDs MGI: 1261813 HomoloGene: 37620 GeneCards: MN1 | ||
MN1 is a gene found on human chromosome 22, with gene map locus 22q12.3-qter. Its official full name is meningioma (disrupted in balanced translocation) 1 because it is disrupted by a balanced translocation (4;22) in a meningioma.
Contents
Function
MN1 is a transcription coregulator that enhances or represses RAR/RXR-mediated gene transcription through interaction with RAC3 and p300. MN1 also acts as a coactivator of the vitamin D receptor.
Clinical significance
Its inactivation may be part of the cause of certain meningiomas. A potential link to leukemia including acute myeloid leukemia has also been described.
References
MN1 (gene) Wikipedia(Text) CC BY-SA