Species Human Entrez 4319 | Human Mouse Ensembl ENSG00000166670 | |
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Aliases MMP10, SL-2, STMY2, matrix metallopeptidase 10 External IDs MGI: 97007 HomoloGene: 20546 GeneCards: MMP10 | ||
Stromelysin-2 also known as matrix metalloproteinase-10 (MMP-10) or transin-2 is an enzyme that in humans is encoded by the MMP10 gene.
Contents
Function
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans and fibronectin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
Clinical significance
MMP10 has been linked to cancer stem cell vitality and metastasis.
References
MMP10 Wikipedia(Text) CC BY-SA