Species Human Entrez 4301 | Human Mouse Ensembl ENSG00000130396 | |
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Aliases AFDN, AF6, MLL-AF6, MLLT4, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4 External IDs MGI: 1314653 HomoloGene: 21202 GeneCards: AFDN | ||
Afadin is a protein that in humans is encoded by the MLLT4 gene.
Contents
Function
AF6 is a Ras (see HRAS; MIM 190020) target that regulates cell–cell adhesions downstream of Ras activation. It is fused with MLL (MIM 159555) in leukemias caused by t(6;11) translocations (Taya et al., 1998).[supplied by OMIM]
Interactions
MLLT4 has been shown to interact with:
References
MLLT4 Wikipedia(Text) CC BY-SA