Species Human Entrez 84365 | Human Mouse Ensembl ENSG00000155438 | |
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Aliases NIFK, MKI67IP, Nopp34, nucleolar protein interacting with the FHA domain of MKI67 External IDs MGI: 1915199 HomoloGene: 49862 GeneCards: NIFK | ||
MKI67 FHA domain-interacting nucleolar phosphoprotein is a protein that in humans is encoded by the MKI67IP gene.
MKI67 FHA domain-interacting nucleolar phosphoprotein contains an RNA recognition motif (RRM) near to the N-terminus and a FHA Ki67 binding domain near to the C-terminus. There are two conserved sequence motifs within the FHA Ki67 binding domain: TPVCTP and LERRKS, this domain binds to the forkhead-associated domain of human Ki67. High-affinity binding requires sequential phosphorylation by two kinases, CDK1 and GSK3, yielding pThr238, pThr234 and pSer230. This interaction is involved in cell cycle regulation.
References
MKI67IP Wikipedia(Text) CC BY-SA