Species Human Entrez 50488 | Human Mouse Ensembl ENSG00000141503 | |
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Aliases MINK1, B55, MAP4K6, MINK, YSK2, ZC3, hMINK, hMINKbeta, misshapen like kinase 1 External IDs MGI: 1355329 HomoloGene: 56762 GeneCards: MINK1 | ||
Misshapen-like kinase 1 is an enzyme that in humans is encoded by the MINK1 gene.
Contents
Function
Misshapen-like kinase 1 is a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified.
Interactions
MINK1 has been shown to interact with NCK1.
References
MINK1 Wikipedia(Text) CC BY-SA