MG132

MG132 is a specific, potent, reversible, and cell-permeable proteasome inhibitor (K_i = 4 nM). It reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. MG132 activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. MG132 also inhibits NF-κB activation with an IC₅₀ of 3 µM and prevents β-secretase cleavage.

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• Jvc gz mg132
• Yucca dideridoo mg132 by myke gomezmaicas
• References