Entrez 112950 | Ensembl ENSG00000159479 | |
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Aliases MED8, ARC32, mediator complex subunit 8 External IDs MGI: 1915269 HomoloGene: 10560 GeneCards: MED8 | ||
Mediator of RNA polymerase II transcription subunit 8 is an enzyme that in humans is encoded by the MED8 gene.
Contents
Function
This gene encodes a protein that is one of more than 20 subunits of the mediator complex, first identified in S. cerevisiae, that is required for activation of transcription. The product of this gene also interacts with elongins B and C, and CUL2 and RBX1, to reconstitute a ubiquitin ligase. Five alternative transcripts encoding four isoforms have been described.
Interactions
MED8 has been shown to interact with MED26.
References
MED8 Wikipedia(Text) CC BY-SA