Entrez 9862 | Ensembl ENSG00000008838 | |
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Aliases MED24, ARC100, CRSP100, CRSP4, DRIP100, THRAP4, TRAP100, MED5, mediator complex subunit 24 External IDs MGI: 1344385 HomoloGene: 40795 GeneCards: MED24 | ||
Mediator of RNA polymerase II transcription subunit 24 is an enzyme that in humans is encoded by the MED24 gene.
Contents
Function
This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for this gene.
Interactions
MED24 has been shown to interact with Estrogen receptor alpha, Cyclin-dependent kinase 8, Calcitriol receptor and BRCA1.
References
MED24 Wikipedia(Text) CC BY-SA