Species Human Entrez 9969 | Human Mouse Ensembl ENSG00000108510 | |
Aliases MED13, ARC250, DRIP250, HSPC221, THRAP1, TRAP240, mediator complex subunit 13 External IDs MGI: 3029632 HomoloGene: 21067 GeneCards: MED13 | ||
Mediator complex subunit 13 is a protein that in humans is encoded by the MED13 gene.
Function
This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator.
References
MED13 Wikipedia(Text) CC BY-SA