Entrez 9968 | Ensembl ENSG00000184634 | |
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Aliases MED12, ARC240, CAGH45, FGS1, HOPA, MED12S, OHDOX, OKS, OPA1, TNRC11, TRAP230, mediator complex subunit 12 External IDs MGI: 1926212 HomoloGene: 68441 GeneCards: MED12 | ||
Mediator of RNA polymerase II transcription, subunit 12 homolog (S. cerevisiae), also known as MED12, is a human gene found on the X chromosome.
Contents
Clinical significance
Mutations in MED12 are responsible for at least two different forms of X-linked dominant mental retardation, Lujan-Fryns syndrome and FG syndrome, as well as instances of prostate cancer.
Mutations in MED12 are associated to uterine leiomyomas and breast fibroepithelial tumors (e.g. fibroadenoma and phyllodes tumors).
Interactions
MED12 has been shown to interact with:
References
MED12 Wikipedia(Text) CC BY-SA