MDFI

Updated on Dec 08, 2024

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Species Human Entrez 4188		Human Mouse Ensembl ENSG00000112559

Aliases MDFI, MyoD family inhibitor, I-MF, I-mfa External IDs MGI: 107687 HomoloGene: 21150 GeneCards: MDFI

MyoD family inhibitor is a protein that in humans is encoded by the MDFI gene.

Function
Interactions
References

Function

This protein is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interferes with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures.

Interactions

MDFI has been shown to interact with:

C9orf86,

GNAI2,

MyoD,

Myogenin, and

SIX1.

References

MDFI Wikipedia

(Text) CC BY-SA

Contents

Function

Interactions

References