Species Human Entrez 4188 | Human Mouse Ensembl ENSG00000112559 | |
 | ||
Aliases MDFI, MyoD family inhibitor, I-MF, I-mfa External IDs MGI: 107687 HomoloGene: 21150 GeneCards: MDFI | ||
MyoD family inhibitor is a protein that in humans is encoded by the MDFI gene.
Contents
Function
This protein is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interferes with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures.
Interactions
MDFI has been shown to interact with:
References
MDFI Wikipedia(Text) CC BY-SA