Species Human Entrez 4173 | Human Mouse Ensembl ENSG00000104738 | |
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Aliases MCM4, CDC21, CDC54, NKCD, NKGCD, P1-CDC21, hCdc21, minichromosome maintenance complex component 4 External IDs MGI: 103199 HomoloGene: 40496 GeneCards: MCM4 | ||
DNA replication licensing factor MCM4 is a protein that in humans is encoded by the MCM4 gene.
Contents
Function
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.
Interactions
MCM4 has been shown to interact with: