Aliases MBD3 Human Mouse Ensembl ENSG00000071655 | Species Human Entrez 53615 | |
 | ||
External IDs MGI: 1333812 HomoloGene: 2917 GeneCards: MBD3 | ||
Gene music using protein sequence of mbd3l1 methyl cpg binding domain protein 3 like 1
Methyl-CpG-binding domain protein 3 is a protein that in humans is encoded by the MBD3 gene.
Contents
Gene music using protein sequence of mbd3l2 methyl cpg binding domain protein 3 like 2
Function
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). However, unlike the other family members, MBD3 is not capable of binding to methylated DNA but instead binds to hydroxymethylated DNA [1]. The predicted MBD3 protein shares 71% and 94% identity with MBD2 (isoform 1) and mouse Mbd3. MBD3 is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. MBD3 mediates the association of metastasis-associated protein 2 (MTA2) with the core histone deacetylase complex.
Interactions
MBD3 has been shown to interact with:
