Species Human Entrez 22919 | Human Mouse Ensembl ENSG00000101367 | |
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Aliases MAPRE1, EB1, microtubule associated protein RP/EB family member 1 External IDs MGI: 891995 HomoloGene: 56129 GeneCards: MAPRE1 | ||
Gene music using protein sequence of mapre1 microtubule associated protein rp eb family member 1
Microtubule-associated protein RP/EB family member 1 is a protein that in humans is encoded by the MAPRE1 gene.
Contents
Function
The protein encoded by this gene was first identified by its binding to the APC (Adenomatous polyposis coli) protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family.
Interactions
MAPRE1 has been shown to interact with TERF1.