Species Human Entrez 9448 | Human Mouse Ensembl ENSG00000071054 | |
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Aliases MAP4K4, FLH21957, HEL-S-31, HGK, MEKKK4, NIK, mitogen-activated protein kinase kinase kinase kinase 4 External IDs MGI: 1349394 HomoloGene: 7442 GeneCards: MAP4K4 | ||
Mitogen-activated protein kinase kinase kinase kinase 4 is an enzyme that in humans is encoded by the MAP4K4 gene.
Contents
Function
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. A recent study showed that MAP4K4 is a direct kinase of LATS1/2 and thus regulates the Hippo pathway effectors YAP and TAZ.
Interactions
MAP4K4 has been shown to interact with NCK1 and CD29.