Species Human Entrez 257397 | Human Mouse Ensembl ENSG00000157625 | |
Aliases TAB3, MAP3K7IP3, NAP1, TGF-beta activated kinase 1/MAP3K7 binding protein 3 External IDs MGI: 1913974 HomoloGene: 17673 GeneCards: TAB3 | ||
Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 is an enzyme that in humans is encoded by the MAP3K7IP3 gene.
Contents
Function
The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Interactions
MAP3K7IP3 has been shown to interact with MAP3K7IP2,MAP3K7IP1 and MAP3K7.