Species Human Entrez 4124 | Human Mouse Ensembl ENSG00000112893 | |
Aliases MAN2A1, AMan II, GOLIM7, MANA2, MANII, mannosidase alpha class 2A member 1 External IDs MGI: 104669 HomoloGene: 1777 GeneCards: MAN2A1 | ||
Alpha-mannosidase 2 is an enzyme that in humans is encoded by the MAN2A1 gene.
Function
This gene encodes a protein which is a member of family 38 of the glycosyl hydrolases. The protein is located in the Golgi apparatus and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-linked glycosylation) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus.
References
MAN2A1 Wikipedia(Text) CC BY-SA