Species Human Entrez 9794 | Human Mouse Ensembl ENSG00000161021 | |
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Aliases MAML1, Mam-1, Mam1, mastermind like transcriptional coactivator 1 External IDs MGI: 1890504 HomoloGene: 8845 GeneCards: MAML1 | ||
Mastermind-like protein 1 is a protein that in humans is encoded by the MAML1 gene.
Contents
Function
This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.
Details on the activity of the N-terminal domain of Mastermind-like protein 1 may be found under MamL-1.
Interactions
MAML1 has been shown to interact with EP300 and NOTCH1.
References
MAML1 Wikipedia(Text) CC BY-SA