Entrez 51176 | Ensembl ENSG00000138795 | |
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Aliases LEF1, LEF-1, TCF10, TCF1ALPHA, TCF7L3, lymphoid enhancer binding factor 1 External IDs MGI: 96770 HomoloGene: 7813 GeneCards: LEF1 | ||
Lymphoid enhancer-binding factor 1 (LEF1) is a protein that in humans is encoded by the LEF1 gene.
Contents
Function
Lymphoid enhancer-binding factor-1 (LEF1) is a 48-kD nuclear protein that is expressed in pre-B and T cells. It binds to a functionally important site in the T-cell receptor-alpha (TCRA) enhancer and confers maximal enhancer activity. LEF1 belongs to a family of regulatory proteins that share homology with high mobility group protein-1 (HMG1).
Clinical significance
LEF1 is highly overexpressed and associated with disease progression and poor prognosis in B-cell chronic lymphocytic leukemia. It is also a promising potential drug target.
Interactions
Lymphoid enhancer-binding factor 1 has been shown to interact with:
References
Lymphoid enhancer-binding factor 1 Wikipedia(Text) CC BY-SA