Rahul Sharma (Editor)

Lymphoid enhancer binding factor 1

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Species
  
Human

Entrez
  
51176

Human
  
Mouse

Ensembl
  
ENSG00000138795

Lymphoid enhancer-binding factor 1

Aliases
  
LEF1, LEF-1, TCF10, TCF1ALPHA, TCF7L3, lymphoid enhancer binding factor 1

External IDs
  
MGI: 96770 HomoloGene: 7813 GeneCards: LEF1

Lymphoid enhancer-binding factor 1 (LEF1) is a protein that in humans is encoded by the LEF1 gene.

Contents

Function

Lymphoid enhancer-binding factor-1 (LEF1) is a 48-kD nuclear protein that is expressed in pre-B and T cells. It binds to a functionally important site in the T-cell receptor-alpha (TCRA) enhancer and confers maximal enhancer activity. LEF1 belongs to a family of regulatory proteins that share homology with high mobility group protein-1 (HMG1).

Clinical significance

LEF1 is highly overexpressed and associated with disease progression and poor prognosis in B-cell chronic lymphocytic leukemia. It is also a promising potential drug target.

Interactions

Lymphoid enhancer-binding factor 1 has been shown to interact with:

  • ALX4,
  • AML-1,
  • CTNNB1,
  • EP300,
  • MITF
  • PIAS4,
  • SMAD2, and
  • SMAD3.

    • References

    Lymphoid enhancer-binding factor 1 Wikipedia
    (Text) CC BY-SA