Lugo is a Spanish surname. People with the surname include:
Alonso Fernández de Lugo (died 1525), Spanish conquistador
Amador Lugo Guadarrama (1921–2002), Mexican artist
Fernando Lugo (born 1951), former president of Paraguay
José del Carmen Lugo (1831–c.1870), Southern California landowner
José Inocente Lugo (1871–1963), Mexican lawyer
Julio Lugo (born 1975), baseball shortstop
Pablo Lugo (born 1932), Puerto Rican boxer
Pedro Fernández de Lugo (1475–1536), second military governor of the Canary Islands
Ruddy Lugo (born 1980), baseball pitcher
