Lucius Calpurnius Piso Frugi was a name used by Roman men of the gens Calpurnia during the Roman Republic and early Empire. They were descendants of the Lucius Calpurnius Piso Frugi who was consul in 133 BC and who established the addition of Frugi as an agnomen that was passed down through the family. The Calpurnii Pisones who distinguished themselves by the name Frugi were one of three main branches of Pisones active from the mid-2nd century BC into the 1st century AD.
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There were four unbroken generations who kept the name Frugi, but the nomenclature of the family line is complicated by adoption in adulthood, a practice of elite Roman families to preserve their heritage, religious traditions (sacra gentilicia), influence and property. One member of this family line (who became the praetor of 112 BC) had been adopted by a Marcus Pupius, and also used the name Marcus Pupius combined with Piso Frugi. His name was rendered Marcus Pupius Piso Frugi Calpurnianus. The name Frugi was used for three more generations, in one case again kept by an adoptee. A fifth-generation descendant of the praetor adopted by M. Pupius went back to using the original form Lucius Calpurnius Piso Frugi, along with Licinianus in reference to a grandfather's adopted name.